Title : The correlation between the methylation of PTEN gene and the apoptosis of osteosarcoma cells mediated by SeHA nanoparticles.

Pub. Date : 2019 Dec 1

PMID : 31541893






4 Functional Relationships(s)
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1 The correlation between the methylation of PTEN gene and the apoptosis of osteosarcoma cells mediated by SeHA nanoparticles. Selenious Acid phosphatase and tensin homolog Homo sapiens
2 Bisulfite Sequence PCR of PTEN gene exhibited about (22.40 +- 5.39)%, (45.91 +- 6.36)% and (25.90 +- 5.36)% promoter methylation in control, HA and SeHA group. Selenious Acid phosphatase and tensin homolog Homo sapiens
3 Compared the methylation status of PTEN gene in each group, it was confirming that SeHA nanoparticles hardly possessed the de-methylation effect, but the pure HA strikingly increased the methylation level of such gene. Selenious Acid phosphatase and tensin homolog Homo sapiens
4 It seemed the dopant selenite ions possessed de-methylation effect onto PTEN gene. Selenious Acid phosphatase and tensin homolog Homo sapiens