Title : Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.

Pub. Date : 2019

PMID : 31539416






1 Functional Relationships(s)
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1 In particular, compounds 3 and 7 exhibit Ki values of 0.036 +- 0.005 muM and 0.036 +- 0.007 muM towards PDE5 respectively, which are approaching those of commercial PDE5 inhibitors, and can effectively reduce GMP levels in cultured human BJ-hTERT cells. guanosine 5'-monophosphorothioate phosphodiesterase 5A Homo sapiens