Title : Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

Pub. Date : 2019 Oct 24

PMID : 31539241






1 Functional Relationships(s)
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1 Herein, we described the design, synthesis, and evaluation of novel proteolysis-targeting chimeric (PROTAC) small molecules targeting BCR-ABL which connect dasatinib and VHL E3 ubiquitin ligase ligand by extensive optimization of linkers. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens