Title : DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.

Pub. Date : 2020 Jul

PMID : 31538542






3 Functional Relationships(s)
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1 In order to shed light on this issue, DRD2- and DRD3-overexpressing cells and drd2 KO, drd3 KO and wild-type mice were treated with the DRD2-DRD3 agonist pramipexole. Pramipexole dopamine receptor D2 Mus musculus
2 In order to shed light on this issue, DRD2- and DRD3-overexpressing cells and drd2 KO, drd3 KO and wild-type mice were treated with the DRD2-DRD3 agonist pramipexole. Pramipexole dopamine receptor D2 Mus musculus
3 The results revealed that pramipexole induces autophagy through MTOR inhibition and a DRD3-dependent but DRD2-independent mechanism. Pramipexole dopamine receptor D2 Mus musculus