| Protein Name | dopamine receptor D2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13489 |
| Gene Symbol | Drd2 |
| UniProt | P61168 (DRD2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
331
Total Number of Articles : 734 |
Description |
dopamine receptor D2 |
| Gene Summary |
Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including hyaloid vascular plexus regression; negative regulation of innate immune response; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including G protein-coupled dopamine receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in axon and dendrite. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Jun 2025] |
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