Pub. Date : 2019 Dec 1
PMID : 31509437
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OATP1B3-1B7 a novel Organic Anion Transporting Polypeptide is modulated by FXR ligands and transports bile acids. | Bile Acids and Salts | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 2 | Applying a heterologous expression system we showed that several bile acids interact with OATP1B3-1B7 and that taurocholic acid and lithocholic acid are OATP1B3-1B7 substrates. | Bile Acids and Salts | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 3 | In accordance are our findings showing that the OATP1B3-1B7 inhibitor bromsulphthalein significantly reduced uptake of bile acids into human liver microsomes. | Bile Acids and Salts | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 4 | Taken together we report that OATP1B3-1B7 transcription can be modulated with FXR agonists and antagonists and that OATP1B3-1B7 transports bile acids. | Bile Acids and Salts | solute carrier organic anion transporter family member 1B3 | Homo sapiens |