Pub. Date : 2019 Sep 5
PMID : 31491956
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells. | Lycopene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | This study aims to investigate whether lycopene inhibits proliferation and induces apoptosis in gastric cancer AGS cells by suppressing the EGFR/Ras/MAPK and NF-kappaB-COX-2 signaling axis. | Lycopene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. | Lycopene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells. | Lycopene | prostaglandin-endoperoxide synthase 2 | Homo sapiens |