Title : CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.

Pub. Date : 2019 Sep 5

PMID : 31488827






1 Functional Relationships(s)
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Protein Name
Organism
1 EGFR-activated CDK5 directly binds to and phosphorylates TRIM59, a ubiquitin ligase at serine 308, which recruits PIN1 for cis-trans isomerization of TRIM59, leading to TRIM59 binding to importin alpha5 and nuclear translocation. Serine epidermal growth factor receptor Homo sapiens