Pub. Date : 2019 Sep 4
PMID : 31484924
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Non-prenylated Rac1 has a high affinity for the adaptor protein Ras GTPase-activating-like protein 1 (Iqgap1), which facilitates both GTP exchange and ubiquitination-mediated degradation of Rac1. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 2 | Non-prenylated Rac1 has a high affinity for the adaptor protein Ras GTPase-activating-like protein 1 (Iqgap1), which facilitates both GTP exchange and ubiquitination-mediated degradation of Rac1. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 3 | Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 4 | Consistently, inactivating Iqgap1 normalizes Rac1 GTP-loading, and reduces inflammation and arthritis in GGTase-I-deficient mice, as well as prevents statins from increasing Rac1 GTP-loading and cytokine production in macrophages. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |