Title : A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis.

Pub. Date : 2020 Jan

PMID : 31477837






1 Functional Relationships(s)
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1 Significantly, we identify FGFR, RET, and MERTK as the first RTKs that can directly interact with and phosphorylate YAP/TAZ at multiple tyrosine residues independent of upstream Hippo signaling, thereby activating their functions in tumorigenesis. Tyrosine MER proto-oncogene, tyrosine kinase Homo sapiens