Title : Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration.

Pub. Date : 2019 Sep 2

PMID : 31477744






4 Functional Relationships(s)
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Protein Name
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1 Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown. Water aquaporin 1 (Colton blood group) Homo sapiens
2 Aquaporin-1 (AQP1) has been proposed as a dual water and cation channel that when upregulated in cancers enhances cell migration rates; however, the mechanism remains unknown. Water aquaporin 1 (Colton blood group) Homo sapiens
3 Previous work identified AqB011 as an inhibitor of the gated human AQP1 cation conductance, and bacopaside II as a blocker of AQP1 water pores. Water aquaporin 1 (Colton blood group) Homo sapiens
4 Results here are the first to demonstrate that combined block of the AQP1 ion channel and water pores is more potent in impairing motility across diverse classes of colon cancer cells than single agents alone. Water aquaporin 1 (Colton blood group) Homo sapiens