Pub. Date : 2019 Oct
PMID : 31473552
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vinpocetine is a nootropic phosphodiesterase-1 (PDE-1) inhibitor that can reverse ketamine-induced schizophrenia-like deficits by increasing BDNF expression. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | RESULTS: Ketamine induced drastic schizophrenia-like behaviors, lower protein levels of BDNF and PSD-95, and a change in the synaptic ultrastructure in the PCC. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | CONCLUSION: Vinpocetine can reverse the synaptic ultrastructure by regulating BDNF-related PSD-95 to alleviate schizophrenia-like deficits induced by ketamine in rats. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |