Title : Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells.

Pub. Date : 2019 Aug 31

PMID : 31472681






3 Functional Relationships(s)
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1 RESULTS: Exposure to 100-400 muM PA reduced cell viability, activated caspase 3, and enhanced the expression levels of the apoptosis-related protein BCL-2-associated X protein (BAX) and ER stress markers glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in MLTC-1 cells. Palmitic Acid BCL2-associated X protein Mus musculus
2 RESULTS: Exposure to 100-400 muM PA reduced cell viability, activated caspase 3, and enhanced the expression levels of the apoptosis-related protein BCL-2-associated X protein (BAX) and ER stress markers glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in MLTC-1 cells. Palmitic Acid BCL2-associated X protein Mus musculus
3 Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78. Palmitic Acid BCL2-associated X protein Mus musculus