Title : Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

Pub. Date : 1988 Aug 23

PMID : 3146347






1 Functional Relationships(s)
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1 Since thrombin has a primary specificity for basic amino acids, each of the three basic residues and the histidine in hirudin were mutated to glutamine. Histidine coagulation factor II, thrombin Homo sapiens