Pub. Date : 2019 Aug 27
PMID : 31461951
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 2 | We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 3 | We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 4 | We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 5 | We also found that the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway resulted in MMP-9 overexpression and nuclear factor-kappaB (NF-kappaB) activation in mice treated with 1,2-DCE. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 6 | In this study, we further hypothesized that inflammatory reactions mediated by the p38 MAPK/ NF-kappaB signaling pathway might be involved in MMP-9 overexpression, blood-brain barrier (BBB) disruption and edema formation in the brain of 1,2-DCE-intoxicated mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |
| 7 | Furthermore, pretreatment with an inhibitor against MMP-9 obstructs the decrease of TJs in the brain of 1,2-DCE-intoxicated mice. | ethylene dichloride | matrix metallopeptidase 9 | Mus musculus |