Pub. Date : 2019
PMID : 31447686
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 2 | Consistently, we previously demonstrated that tamoxifen (TAM), a selective estrogen receptor modulator, attenuates the downregulation of AQP2 in lithium-induced nephrogenic diabetes insipidus (NDI). | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 3 | Consistently, we previously demonstrated that tamoxifen (TAM), a selective estrogen receptor modulator, attenuates the downregulation of AQP2 in lithium-induced nephrogenic diabetes insipidus (NDI). | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 4 | In this study, we investigated the AVP-independent regulation of AQP2 by TAM and the therapeutic effect of TAM on the dysregulation of AQP2 and impaired urinary concentration in a unilateral ureteral obstruction (UUO) model. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 5 | In this study, we investigated the AVP-independent regulation of AQP2 by TAM and the therapeutic effect of TAM on the dysregulation of AQP2 and impaired urinary concentration in a unilateral ureteral obstruction (UUO) model. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 6 | TAM induced AQP2 protein expression and intracellular trafficking in primary cultured IMCD cells, which were independent of the vasopressin V2 receptor (V2R) and cAMP activation, the critical pathways involved in AVP-stimulated regulation of AQP2. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 7 | TAM induced AQP2 protein expression and intracellular trafficking in primary cultured IMCD cells, which were independent of the vasopressin V2 receptor (V2R) and cAMP activation, the critical pathways involved in AVP-stimulated regulation of AQP2. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 8 | TAM attenuated the downregulation of AQP2 in TGF-beta treated IMCD cells and IMCD suspensions prepared from UUO rats. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 9 | TAM administration in vivo attenuated the downregulation of AQP2, associated with an improvement of urinary concentration in UUO rats. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 10 | In addition, TAM increased CaMKII expression, suggesting that calmodulin signaling pathway is likely to be involved in the TAM-mediated AQP2 regulation. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 11 | In addition, TAM increased CaMKII expression, suggesting that calmodulin signaling pathway is likely to be involved in the TAM-mediated AQP2 regulation. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 12 | In conclusion, TAM is involved in AQP2 regulation in a vasopressin-independent manner and improves urinary concentration by attenuating the downregulation of AQP2 and maintaining intracellular trafficking in UUO. | Tamoxifen | aquaporin 2 | Rattus norvegicus |
| 13 | In conclusion, TAM is involved in AQP2 regulation in a vasopressin-independent manner and improves urinary concentration by attenuating the downregulation of AQP2 and maintaining intracellular trafficking in UUO. | Tamoxifen | aquaporin 2 | Rattus norvegicus |