Title : Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway.

Pub. Date : 2019 Dec 5

PMID : 31445131






2 Functional Relationships(s)
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1 Furthermore, pretreatment of TGP conducted the protection for dopaminergic neurons with the prevented MPTP-induced reductions within the tyrosine hydroxylase (TH), substantia nigra dopaminergic transporter (DAT), as well as increasing alpha-synuclein protein levels with transformed dopamine catabolism as well as inhibited dopamine turnover. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
2 Furthermore, pretreatment of TGP conducted the protection for dopaminergic neurons with the prevented MPTP-induced reductions within the tyrosine hydroxylase (TH), substantia nigra dopaminergic transporter (DAT), as well as increasing alpha-synuclein protein levels with transformed dopamine catabolism as well as inhibited dopamine turnover. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus