Title : ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.

Pub. Date : 2019 Aug 23

PMID : 31443721






1 Functional Relationships(s)
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1 ITCH-silencing or CI concomitantly abrogated HER3-specific antibody-induced apoptosis of Annexin V/7-AAD-labelled BxPC3 cells. 7-aminoactinomycin D itchy E3 ubiquitin protein ligase Homo sapiens