CPRiL

ITCH

itchy E3 ubiquitin protein ligase

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

• E3 ubiquitin-protein ligase Itchy homolog
• HECT-type E3 ubiquitin transferase Itchy homolog
• NFE2-associated polypeptide 1
atrophin-1 interacting protein 4
itchy E3 ubiquitin protein ligase homolog
ADMFD
AIF4
AIP4
NAPP1