Pub. Date : 2019 Aug 22
PMID : 31442404
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies, including beta-hydroxybutyrate (betaOHB), distinguishes self-renewing Lgr5+ stem cells (ISCs) from differentiated cell types. | betaohb | NFS1 cysteine desulfurase | Homo sapiens |
| 2 | Hmgcs2 loss depletes betaOHB levels in Lgr5+ ISCs and skews their differentiation toward secretory cell fates, which can be rescued by exogenous betaOHB and class I histone deacetylase (HDAC) inhibitor treatment. | betaohb | NFS1 cysteine desulfurase | Homo sapiens |
| 3 | Hmgcs2 loss depletes betaOHB levels in Lgr5+ ISCs and skews their differentiation toward secretory cell fates, which can be rescued by exogenous betaOHB and class I histone deacetylase (HDAC) inhibitor treatment. | betaohb | NFS1 cysteine desulfurase | Homo sapiens |
| 4 | These findings reveal how control of betaOHB-activated signaling in ISCs by diet helps to fine-tune stem cell adaptation in homeostasis and injury. | betaohb | NFS1 cysteine desulfurase | Homo sapiens |