Protein Name NFS1 cysteine desulfurase
Organism Homo sapiens
Gene ID 9054
Gene Symbol

NFS1

UniProt Q9Y697 (NFS1_HUMAN), Q53FP3 (Q53FP3_HUMAN)
Relationships Total Number of functionally related compound(s) : 95
Total Number of Articles : 126
Description

NFS1 cysteine desulfurase

Gene Summary

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

synonyms
  • cysteine desulfurase
  • NFS1 nitrogen fixation 1 homolog
  • cysteine desulfurase, mitochondrial
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Properties