Title : [Synthesis and evaluation of N-alkynylaminosteroids as potential CYP450 17A1 inhibitors].

Pub. Date : 2019 Jun

PMID : 31436174






1 Functional Relationships(s)
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1 Four isomeric dehydroepiandrosterone- and pregnenolone-based N-alkynylaminosteroids were synthesized and tested in vitro for inhibition of heterologously expressed CYP17A1. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens