Title : A randomized pilot study to investigate the effect of opioids on immunomarkers using gene expression profiling during surgery.

Pub. Date : 2019 Dec

PMID : 31433352






1 Functional Relationships(s)
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1 Statistically significant increases in IL-6 concentrations were induced by morphine only; NK cell activity was suppressed with morphine, but maintained with oxycodone and epidural analgesia.Gene expression profiles suggest that at 2 h post-incision morphine appeared to be immunosuppressive as compared to oxycodone and non-opioid control analgesia. Morphine interleukin 6 Homo sapiens