Pub. Date : 2019 Nov
PMID : 31432177
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 2 | Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 3 | These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle- and EMT-related regulators, in order to block cell proliferation and metastasis in NSCLC. | Curcumin | epidermal growth factor receptor | Homo sapiens |