Title : Molecular mechanisms of Cisplatin- induced placental toxicity and teratogenicity in rats and the ameliorating role of N-acetyl-cysteine.

Pub. Date : 2019 Oct

PMID : 31401317






2 Functional Relationships(s)
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1 Importantly, NAC attenuated Cisplatin-induced placental apoptosis through down-regulation of Fas and Caspase-3 genes expression. Cisplatin caspase 3 Rattus norvegicus
2 In conclusion, induction of placental apoptosis by overexpression of Fas and Caspase-3 genes gives a new insight into the mechanism of Cisplatin teratogenicity. Cisplatin caspase 3 Rattus norvegicus