Title : Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia.

Pub. Date : 2020 May

PMID : 31399521






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further analyses of murine cell lines and primary patient material indicate that active BCR-ABL directly interacts with Beclin-1 and phosphorylates its tyrosine residues 233 and 352, resulting in autophagy suppression. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens