Pub. Date : 2020 Jan 1
PMID : 31398381
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Using an integrative approach combing electrophysiological and cellular mechanisms, the results showed that the impaired eCB-LTD, abnormal mGluR-mediated LTD (mGluR-LTD) and decreased removal of AMPAR subunits GluA1 and GluA2 were reversed by URB597 in the prefrontal cortex (PFC) of VPA-exposed offspring. | cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
2 | Taken together, these results provide the first evidence that rescue of the ASD-like phenotype by URB597 is mediated by enhancing the mechanism of removal of AMPAR subunits GluA1/2 underlying AEA signaling in the PFC in a VPA-induced model of ASD. | cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
3 | Taken together, these results provide the first evidence that rescue of the ASD-like phenotype by URB597 is mediated by enhancing the mechanism of removal of AMPAR subunits GluA1/2 underlying AEA signaling in the PFC in a VPA-induced model of ASD. | cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |