Pub. Date : 2019 Aug 8
PMID : 31391337
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we demonstrate that the FDA-approved drug niclosamide, a potent inhibitor of TMEM16A identified by high-throughput screening, is an inhibitor of both TMEM16A and TMEM16F. | Niclosamide | anoctamin 1, calcium activated chloride channel | Mus musculus |
| 2 | Here we demonstrate that the FDA-approved drug niclosamide, a potent inhibitor of TMEM16A identified by high-throughput screening, is an inhibitor of both TMEM16A and TMEM16F. | Niclosamide | anoctamin 1, calcium activated chloride channel | Mus musculus |
| 3 | TMEM16A and TMEM16F support exocytic release of mucus and inflammatory mediators, both of which are blocked by niclosamide. | Niclosamide | anoctamin 1, calcium activated chloride channel | Mus musculus |