| Protein Name | anoctamin 1, calcium activated chloride channel |
|---|---|
| Organism | Mus musculus |
| Gene ID | 101772 |
| Gene Symbol | Ano1 |
| UniProt | Q8BHY3 (ANO1_MOUSE), A0A0A0MQF2 (A0A0A0MQF2_MOUSE), G8JL82 (G8JL82_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
129
Total Number of Articles : 125 |
Description |
anoctamin 1, calcium activated chloride channel |
| Gene Summary |
Enables intracellularly calcium-gated chloride channel activity; protein homodimerization activity; and voltage-gated chloride channel activity. Involved in several processes, including chloride transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; and mucus secretion. Acts upstream of or within establishment of localization in cell and regulation of membrane potential. Located in apical plasma membrane and external side of plasma membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Jul 2025] |
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