Title : Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma.

Pub. Date : 2019

PMID : 31384313






3 Functional Relationships(s)
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1 The effects of BAY1143572 and 5-FU on MCL-1 in vitro were analyzed by Western blotting, quantitative real-time polymerase chain reaction, and chromatin immunoprecipitation assay. Fluorouracil MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 5-FU enhanced BAY1143572-induced MCL-1 downregulation and stable MCL-1 overexpression reduced the apoptosis induced by BAY1143572 and 5-FU in vitro. Fluorouracil MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 5-FU enhanced BAY1143572-induced MCL-1 downregulation and stable MCL-1 overexpression reduced the apoptosis induced by BAY1143572 and 5-FU in vitro. Fluorouracil MCL1 apoptosis regulator, BCL2 family member Homo sapiens