Pub. Date : 2019 Nov 15
PMID : 31382115
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. | spinetoram | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Intracellular biochemical assay indicated that decrease of mitochondrial membrane potential, LC3-II conversion, accumulation of Beclin-1, degradation of p62 and the changes in the phosphorylation of AMPK, mTOR are contributed to the toxic effects of Spinetoram on HepG2 cells. | spinetoram | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | These results showed that the cytotoxicity of spinetoram may be associated with the activity of AMPK/mTOR-mediated autophagy pathway. | spinetoram | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | We conclude that spinetoram has a significant cytotoxic effect by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. | spinetoram | mechanistic target of rapamycin kinase | Homo sapiens |