Pub. Date : 2020 Aug
PMID : 31375978
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ibrutinib as a potential therapeutic option for HER2 overexpressing breast cancer - the role of STAT3 and p21. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Ibrutinib is a recently approved Tyrosine Kinase Inhibitor (TKI) that has been shown be an effective therapeutic option for HER2 overexpressing breast cancer. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | The molecular mechanisms, pathways, or genes that are modulated by ibrutinib and the mechanism of action of ibrutinib in HER2 overexpressing breast cancer remain obscure. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | In this study, we have performed a kinome array analysis of ibrutinib treatment in two HER2 overexpressing breast cancer cell lines. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | These results suggest that inhibitors of STAT3 phosphorylation may be potential options for combination therapy to help increase the efficacy of ibrutinib against HER2-overexpressing tumors. | ibrutinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |