Title : Novel prodrugs of decitabine with greater metabolic stability and less toxicity.

Pub. Date : 2019 Aug 1

PMID : 31370878






2 Functional Relationships(s)
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1 Nevertheless, it is difficult to achieve stable pharmacokinetics with the current DNA-demethylating agents, azacitidine (AZA) and decitabine (DAC), because of their rapid deamination by cytidine deaminase in vivo and spontaneous hydrolytic cleavage. Decitabine cytidine deaminase Homo sapiens
2 Nevertheless, it is difficult to achieve stable pharmacokinetics with the current DNA-demethylating agents, azacitidine (AZA) and decitabine (DAC), because of their rapid deamination by cytidine deaminase in vivo and spontaneous hydrolytic cleavage. Decitabine cytidine deaminase Homo sapiens