Protein Name cytidine deaminase
Organism Homo sapiens
Gene ID 978
Gene Symbol

CDA

UniProt P32320 (CDD_HUMAN)
Relationships Total Number of functionally related compound(s) : 332
Total Number of Articles : 723
Description

cytidine deaminase

Gene Summary

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

synonyms
  • cytidine deaminase
  • cytidine aminohydrolase
  • cytosine nucleoside deaminase
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Properties