Title : Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.

Pub. Date : 2019 Dec

PMID : 31369697






1 Functional Relationships(s)
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1 In adults with X-linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25-dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. 1,25-dihydroxyvitamin D fibroblast growth factor 23 Homo sapiens