Title : SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.

Pub. Date : 2020 Mar

PMID : 31367013






2 Functional Relationships(s)
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1 Mass spectrometry analysis found that 4-HNE directly modifies cysteine residues (Cys513, 518) on KEAP1, thus leading KEAP1/NRF2 pathway activation and increases the expression levels of NRF2 target genes, such as TXNRD1. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens
2 Mass spectrometry analysis found that 4-HNE directly modifies cysteine residues (Cys513, 518) on KEAP1, thus leading KEAP1/NRF2 pathway activation and increases the expression levels of NRF2 target genes, such as TXNRD1. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens