Pub. Date : 2019 Jul-Sep
PMID : 31360147
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-gamma, and AMPK Expressions. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
2 | Western blot analysis revealed that STZ-induced alterations in adenosine monophosphate protein kinase (AMPK; Thr-172) and protein phosphatase 2C-alpha protein expressions in dorsal root ganglia were inhibited by berberine. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
3 | In conclusion, berberine exerts its neuroprotective effect against n-STZ-induced diabetic peripheral neuropathy via modulation of pro-inflammatory cytokines (TNF alpha, IL-1beta, and IL-6), oxido-nitrosative stress, BDNF, IGF-1, PPAR-gamma, and AMPK expression to ameliorate impaired allodynia, hyperalgesia, and nerve conduction velocity during T2DM. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |