Title : Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-γ, and AMPK Expressions.

Pub. Date : 2019 Jul-Sep

PMID : 31360147






3 Functional Relationships(s)
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1 Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-gamma, and AMPK Expressions. Berberine protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Western blot analysis revealed that STZ-induced alterations in adenosine monophosphate protein kinase (AMPK; Thr-172) and protein phosphatase 2C-alpha protein expressions in dorsal root ganglia were inhibited by berberine. Berberine protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 In conclusion, berberine exerts its neuroprotective effect against n-STZ-induced diabetic peripheral neuropathy via modulation of pro-inflammatory cytokines (TNF alpha, IL-1beta, and IL-6), oxido-nitrosative stress, BDNF, IGF-1, PPAR-gamma, and AMPK expression to ameliorate impaired allodynia, hyperalgesia, and nerve conduction velocity during T2DM. Berberine protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus