PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31360147-0 2019 Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-gamma, and AMPK Expressions. Berberine 23-32 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 129-133 31360147-11 2019 Western blot analysis revealed that STZ-induced alterations in adenosine monophosphate protein kinase (AMPK; Thr-172) and protein phosphatase 2C-alpha protein expressions in dorsal root ganglia were inhibited by berberine. Berberine 212-221 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 103-107 31360147-13 2019 In conclusion, berberine exerts its neuroprotective effect against n-STZ-induced diabetic peripheral neuropathy via modulation of pro-inflammatory cytokines (TNF alpha, IL-1beta, and IL-6), oxido-nitrosative stress, BDNF, IGF-1, PPAR-gamma, and AMPK expression to ameliorate impaired allodynia, hyperalgesia, and nerve conduction velocity during T2DM. Berberine 15-24 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 245-249