Title : Quantitative Prediction of CYP3A4- and CYP3A5-Mediated Drug Interactions.

Pub. Date : 2020 Jan

PMID : 31356678






1 Functional Relationships(s)
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1 The observed CYP3A5 genetic effect on MDZ systemic and oral clearance was successfully replicated by a mechanistic framework incorporating the proteomics-informed CYP3A abundance and optimized small intestinal CYP3A4 abundance based on MDZ intestinal availability (FG ) of 0.44. Midazolam cytochrome P450 family 3 subfamily A member 5 Homo sapiens