Title : The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant "neoplastic" steroidogenesis in adrenals.

Pub. Date : 2019 Oct

PMID : 31351131






2 Functional Relationships(s)
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1 All the key enzymes related to aldosterone and cortisol biosynthesis including CYP11B2, CYP17A1 and CYP11B1 were upregulated by PTH treatment in this model and PTH could serve as a co-stimulator of ANG II to increase CYP11B2 expression. Hydrocortisone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 PTH1R mRNA levels were positively correlated with those of CYP17A1 and CYP11B1, both involved in cortisol production. Hydrocortisone cytochrome P450 family 17 subfamily A member 1 Homo sapiens