Title : Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ.

Pub. Date : 2019 Aug 20

PMID : 31350177






2 Functional Relationships(s)
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Protein Name
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1 Treg cells suppressed CD8+ T cell secretion of interferon-gamma (IFNgamma), which would otherwise block the activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated fatty acid synthesis in immunosuppressive (M2-like) tumor-associated macrophages (TAMs). Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus
2 Treg cells suppressed CD8+ T cell secretion of interferon-gamma (IFNgamma), which would otherwise block the activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated fatty acid synthesis in immunosuppressive (M2-like) tumor-associated macrophages (TAMs). Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus