Protein Name sterol regulatory element binding transcription factor 1
Organism Mus musculus
Gene ID 20787
Gene Symbol

Srebf1

UniProt Q9WTN3 (SRBP1_MOUSE)
Relationships Total Number of functionally related compound(s) : 409
Total Number of Articles : 677
Description

sterol regulatory element binding transcription factor 1

Gene Summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]

synonyms
  • sterol regulatory element-binding protein 1
  • adipocyte determination- and differentiation-dependent factor 1
  • ADD1
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Properties