Title : Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2.

Pub. Date : 2020 Jan

PMID : 31341258






3 Functional Relationships(s)
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Protein Name
Organism
1 Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2. Acyclovir solute carrier family 22 member 6 Homo sapiens
2 Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multidrug resistance-associated protein (MRP) 2. Acyclovir solute carrier family 22 member 6 Homo sapiens
3 TER (5 mumol/L) significantly inhibited the uptake of acyclovir in hOAT1/3-HEK293 cells. Acyclovir solute carrier family 22 member 6 Homo sapiens