Title : Specific inhibition of PI3Kδ/γ enhances the efficacy of anti-PD1 against osteosarcoma cancer.

Pub. Date : 2019 Jun

PMID : 31334002






1 Functional Relationships(s)
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1 Here we demonstrated functional inhibition of G-MDSCs with (S)-(-)-N-[2-(3-Hydroxy-1H-indol-3-yl)-methyl]-acetamide (SNA), a specific inhibitor of PI3Kdelta/gamma, could prime tumor microenvironment, resultantly enhancing the therapeutic efficacy of anti-PD1 treatment in a syngeneic osteosarcoma tumor model. (s)-(-)-N-[2-(3-hydroxy-1h-indol-3-yl)-methyl]-acetamide phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens