Pub. Date : 2019 Jul 20
PMID : 31325292
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro. | oxymatrine | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | OMT alleviated the elevated levels of alpha-SMA, Collagen I, Collagen III, and CTGF, which were abrogated by the Nrf2 siRNA transfection. | oxymatrine | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | CONCLUSIONS Our results confirm that OMT alleviates transdifferentiation of cardiac fibroblasts to myofibroblasts induced by aldosterone via activating the Nrf2/Keap1 pathway in vitro. | oxymatrine | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |