Pub. Date : 2019 Aug 23
PMID : 31321978
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions were biosynthesized. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 2 | In humans, FK506 binds to FK506-binding protein (FKBP) 12, and the resulting FKBP12-FK506 complex interacts with a Ca2+-calmodulin-dependent phosphatase, calcineurin (CaN). | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 3 | In humans, FK506 binds to FK506-binding protein (FKBP) 12, and the resulting FKBP12-FK506 complex interacts with a Ca2+-calmodulin-dependent phosphatase, calcineurin (CaN). | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 4 | In humans, FK506 binds to FK506-binding protein (FKBP) 12, and the resulting FKBP12-FK506 complex interacts with a Ca2+-calmodulin-dependent phosphatase, calcineurin (CaN). | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 5 | Inactivation of CaN by forming the FKBP12-FK506-CaN ternary complex prevents the activation of nuclear factor of activated T cells (NF-AT), inhibiting the production of interleukin-2 and subsequent T-cell proliferation. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 6 | Therefore, the synthesis of FK506 analogues that can discriminate human FKBP12/CaN from its fungal counterparts may separate antifungal activity from the immunosuppressive activity, thereby allowing the development of a novel antifungal agent. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |