Title : Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.

Pub. Date : 2019 Jul 18

PMID : 31321577






1 Functional Relationships(s)
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1 Although no PK change was noticed after a single coadministration, significantly decreased plasma and brain concentrations of CBZ and CBZE with inhibited rat liver Cyp3a2 were demonstrated after long-term combined administration. Carbamazepine cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus