Title : Establishment of Nrf2-deficient HaCaT and immortalized primary human foreskin keratinocytes and characterization of their responses to ROS-induced cytotoxicity.

Pub. Date : 2019 Dec

PMID : 31319135






3 Functional Relationships(s)
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1 Reduced expression of NADPH dehydrogenase quinone 1 (NQO-1) and heme oxygenase 1 (HO-1) genes, which are well-characterized downstream targets of Nrf2-mediated transactivation, was also confirmed by using ALA and another Nrf2 activator, marliolide. marliolide NFE2 like bZIP transcription factor 2 Homo sapiens
2 Interestingly, pretreatment of either ALA or marliolide conferred protection against the ROS induction and the subsequent development of cytotoxicity by menadione in both HaCaT and iHFK cells regardless of the Nrf2 status. marliolide NFE2 like bZIP transcription factor 2 Homo sapiens
3 These data suggest a possibility for activation of Nrf2-independent ROS detoxification pathways by either ALA or marliolide. marliolide NFE2 like bZIP transcription factor 2 Homo sapiens