Title : Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs.

Pub. Date : 2019 Oct

PMID : 31316183






1 Functional Relationships(s)
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1 Bioinformatics study revealed that dipeptidyl peptidase-4 (DPP4) was a target gene of NF-kappaB; DPP4 inhibitor, sitagliptin (10-500 muM) effectively inhibited the abnormal wound healing of PASMCs under hypoxic condition. Sitagliptin Phosphate nuclear factor kappa B subunit 1 Homo sapiens