Title : A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.

Pub. Date : 2019 Jul 30

PMID : 31311871






2 Functional Relationships(s)
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1 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens